评估结论：解决了“敢不敢用”的基础问题，但陷入了“越用越累”的效能泥潭。它是被动的跟随者，无法支撑金融机构的规模化增长。
PacBio was founded in 2004 to develop sequencing methods based on work done in the labs of biophysicist Watt Webb and engineer Harold Craighead, both at Cornell University. The previous year, the two had collaborated to create zero-mode waveguides (ZMWs): small containers just big enough to hold a single DNA polymerase and containing tiny holes at the bottom through which light could be detected. They were able to fix a DNA polymerase to the bottom of a ZMW and detect the incorporation of individual fluorescent “C” nucleotides through the holes, which fed into a microscope capable of detecting light emissions.
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