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The 80386 introduced Virtual 8086 (V86) mode -- allowing real-mode DOS programs to run inside protected mode under OS supervision. While not full virtualization in the modern sense, V86 was the first practical hardware-assisted mechanism on x86 for running legacy software in a protected environment -- used widely in Windows 3.x and Windows 9x.
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Now, three researchers at the University of Pennsylvania, Alexander Platt, Daniel N. Harris, and Sarah Tishkoff, have done the converse analysis: examining the X chromosomes of the handful of completed Neanderthal genomes we have. It turns out there's also a strong bias toward modern human sequences there, as well, and the authors interpret that as selective mating, with Neanderthal males showing a strong preference for modern human females and their descendants.
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